I have been to many resorts with safes and had no problems. But I don't think any of the places I am staying at have safes, so maybe the best thing is to lock my stuff in my suitcase. Where do you keep your wallet?
Most places seem to have at least a front desk safe. I use these liberally when there is no in-room safe. I don't mind bugging the front desk staff a lot -- it's better than the alternative.
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