clarification: a few miles south can be done by taxi or golfcart. a few miles north may require use of a water taxi (the cart path is only passable north of the bridge to a point, and after depending on road condition, can be impassable). if you go into town a lot, it might be a small hassle. if you are looking to veg on a gorgeous beach/pool, north is great.
it DOES depend on what you want. up north, beaches are very pretty, and the resorts are quiet. more of that 'blue lagoon' feel. in town is louder, closer to the bars, music and action. south is a cross between the two.
start with figuring out what you want (party, tranquility, etc) and how much you want to spend per nite, then use the 'lodging' function to narrow down to what you're looking for.