If you can afford to, do this:
Save your data (personal things) to an external backup
Make sure you have all your apps and specialized software on CDs
Make sure you have your original Windows OS
Wipe the hard drive
Reninstall Windows OS
Run updates
Download the spyware/malware apps - run them
Reinstall personal and softwares
Run spyware/malware again
Install anti virus (purchase this!) run it
Stay up to date on Windows Critical updates
Stay up to date on spyware/malware and anti virus
Whew...have a few Belikins in there somewhere too.